Lectins isolated from the seeds and leaves of nettle have been evaluated for a potential role in the management of diabetes. The stinging hairs of most nettle species contain formic acid, serotonin and histamine; however recent studies of Urtica ... Chen R F, Ding W H, Kuo-Huang L L, Huang R N (2006). Brad Parscale: Trump could have 'won by a landslide', 'Lost my mind': Miss Utah's mental illness battle, Hiker recounts seeing monolith removed from desert, ESPN's Herbstreit apologizes for Michigan comments, Baby born from 27-year-old frozen embryo is new record, 'Voice' fans outraged after brutal results show, DeVos rips debt forgiveness, calls free college 'socialist', 5 killed after car drives into pedestrians in Germany, Former Bears player rips Jay Cutler's leadership abilities, GOP leaders silent on violent threats made by Trump allies, Singer reluctantly steps into role of body-positivity icon. Originally native to Europe, much of temperate Asia and western North Afr Top conditions when nettle leaf tea offers relief. The possibility of oral toxicity with nettle preparations is considered low. The spines of stinging nettle contain formic acid, histamine, acetylcholine, and serotonin, which together cause pain and inflammation on contact with skin. Jenny's average annual income over a 4-year period was $25,000. Stinging nettle (Urtica dioica L.) is a medicinal and edible plant species with a. Nettles also are high in anti-inflammatory flavonoids, and they contain small amounts of plant sterols. However, the roots also contain some compounds not found in the leaves, such as fatty acids, plant sterols, secoisolariciresinol, vanillin, and scopoletin [ 2 , 14 , 15 ]. Resolves kidney problems: Nettle leaf tea is a powerful diuretic and depurative. Consuming licorice daily for several weeks or longer can cause severe adverse. In the case of gout, this uric acid builds up and crystallizes around the joints, causing inflammation and excruciating pain. Nettle fruit contains protein, mucilage, and fixed oil (primarily carvacrol [38%], carvone [9%], and naphthalene [9%]).2, 9, 10, 11, High-performance liquid chromatography, gas chromatography, capillary electrophoresis, and other methods have identified the lectin specific to U. dioica roots, which may help to standardize preparations.2, 7, 8, 12, In vitro studies using human cell lines suggest extracts may down-regulate the inflammation cascade, exert effects on cyclo-oxygenase enzymes, and reduce primary T-cell responses.13, 14, 15, 16, 17, 18, 19, In writhing and licking tests in rodent studies, extracts of U. dioica showed analgesic and antinociceptive properties. Balance Blood Sugar – Stinging nettle is well known for balancing blood sugar levels. Now ask them to repeat their experiment - this time testing dock leaves- to see if the hypothesis is correct. Nettle leaves must first be cooked or steamed to destroy the hairs on them, which contain a number of irritating chemicals. Can a person go to jail because of unployement fraud ? The stinging nettle plant has tiny little needle-like projections all over the leaves and stems. In Urtica thunbergiana, individual hairs contain around 4 nanolitres (4 × 10 −6 ml) of … That’s … 3. One of these chemicals is formic acid , which causes the painful rash. Their stings cause tingling, inflamation and pain. It has dark green serrated leaves that grow opposite one another along the stalk and bristles that transmit irritating principles upon contact. Stinging nettle is a powerhouse of nutrients. Nettle leaves must first be cooked or steamed to destroy the hairs on them, which contain a number of irritating chemicals. The leaves contain about 4.8 mg chlorophyll per gram of dry leaves, depending on whether the plant was grown in the sun or shade. Fresh nettle preparations sting a bit, and it is this sting that seems to have a healing effect: The reddening and stinging of the skin appear to reduce the inflammatory processes of dermatologic conditions (such as eczema) and rheumatic conditions (such as arthritis and gout). Nettle root has 5-alpha reductase enzyme blocking properties and is thus beneficial for conditions associated with an enlarged prostate, such as frequent or difficult urination. Stinging nettle root contains several biologically active chemicals that may influence the prostate indirectly by interacting with sex hormones, or directly by altering the properties of prostate cells. You should talk with your health care provider for complete information about the risks and benefits of using this product. Stinging nettle also does an excellent job accelerating skin healing and preventing infection when a … Consequently, it makes sense that rest of the plant contains a number of materials that protect its interior structures from its own poisons. Stinging hairs of Urtica species have been studied in some detail. Health Benefits of … Identification of oxalic acid and tartaric acid as major persistent pain-inducing toxins in the stinging hairs of the nettle, Urtica thunbergiana. The skin surrounding the hives may be red. The nettle plant has an erect stalk that grows up to 1 m in height. Nettles are primarily known for their ability to induce acute urticaria following contact with exposed skin. Nettles are considered to be nourishing plants and have been used to treat scurvy. Therefore the hypothesis is not Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Stinging nettle can be eaten on its own or as an ingredient in foods. Brushing against stinging nettle can cause a mild to moderate rash, d… Stinging nettles may bring relief upon people who have excess uric acid built up in their bodies. (Mosquitoes and biting ants also secrete formic acid, which is responsible for the familiar stinging and itching of their bites.) It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It has deeply toothed leaves and fine hairs that release histamines and formic acid when touched; these substances are similar to the compounds released by bees or fire ants, according to Purdue University. 2. Freeze-dried nettle has been evaluated for allergic rhinitis; in a double-blind trial, 600 mg of freeze-dried nettle leaf was more effective than placebo in controlling symptoms.91 Effects may be due to immunomodulatory or anti-inflammatory actions.14, 18, 92, 93, 94 Other immune effects have been described following in vitro studies, including a cellular response greater than that evoked by Echinacea tincture.95 Beluga sturgeon fed nettles showed increased neutrophil and red blood cell counts, as well as increased hemoglobin and hematocrit values.96, Dosages of 600 mg of freeze-dried nettle leaf have been used in a clinical trial for allergic rhinitis.91 Clinical trials for BPH have used aqueous extracts of U. dioica root in dosages of 360 mg daily over 6 months35 and methanol root extract in dosages of 600 to 1,200 mg daily for 6 to 9 weeks.2, Avoid use. Nettle sting also contains seratonin and histamine. Mechanism is the release of inflammatory mediators from mast cells or basophilic leukocytes, both of which have high-affinity receptors for IgE. The stinging trichomes of nettle contain amines, including histamine, serotonin, and choline. The roots and stem have little action, while the leaves and seeds demonstrate high activity. dioica Scientific classification Kingdom: Plantae Clade: Tracheophytes Clade: Angiosperms Clade: Eudicots Clade: Rosids Order: Rosales Family: Urticaceae Genus: Urtica Species: U. dioica Binomial name Urtica dioica L. Urtica dioica, often known as common nettle, stinging nettle or nettle leaf, or just a nettle or stinger, is a herbaceous perennial flowering plant in the family Urticaceae. The exact details are still unknown but it is the histamine that causes the initial reaction when you are stung. The plant flowers from June to September and its fruit is a small, oval-shaped seed approximately 1 mm wide and yellow-brown in color.1, 2, 3, Although known for its stinging properties, the nettle plant has been used in traditional medicine as a diuretic, antispasmodic, and expectorant, as well as in the treatment of asthma. Touch it with a piece of blue litmus paper. Omega 3 Fatty Acids Alpha linoleic acid better known as o mega 3 fatty acids is an essential fat we must get from diet. John Leguizamo slams Latinx support for Trump The nettle sting makes the skin tingle before your own serotonin gets to work to heal blemishes and redness leaving you with a lifted, more radiant complexion. Run cold water over your sting, then use a soft tissue, cold water, … because it contains an alkali which neutralises (or cancels out) the acid of the nettle venom. 20, 21, 22, 23, Experiments in rats, including induced pancreatitis, colitis, and biliary obstruction, showed that nettle extracts reduce proinflammatory cytokines and markers, and also protect against tissue damage.24, 25, 26, Limited clinical trials using nettle leaves to reduce pain associated with osteoarthritis have been conducted.27, 28 The methodological quality of these small studies is limited29, 30; however, further clinical trials may be warranted based on self-reported measures.31, Experimental studies suggest a number of possible mechanisms of action of nettle extracts in managing symptoms of BPH. Stinging nettle (Urtica dioica L.) grows wild in forests, fields and near woodlands in many parts of the U.S. Sixteen free amino acids have been found in the leaves, as well as high silicon levels in the leaves, stems and roots. Making a stinging nettle smoothie. Please name all of the presidential/respectable qualities of Trump. However, some evidence suggests that certain nettle extracts do exhibit efficacy in reducing symptoms of BPH, as measured by International Prostate Symptom Score (IPSS).2, 9, 32, 33, Improved IPSS scores have been demonstrated in limited placebo-controlled, randomized clinical studies.35, 36, 37 Three clinical studies examined nettle extracts over 8 weeks,37 1 year,36 and 6 months35 in population sizes of 100, 246, and 558 participants, respectively. Nettle leaf is among effective herbs used to treat allergies, kidney problems, skin problems and urinary tract infection. Surprisingly, more chlorophyll and carotenoids are found in plants that have been grown in the shade. The nettle has sharp hairs on its leaves. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Wash it. Stinging nettle rash occurs when the skin comes into contact with stinging nettles. Drugs can help to ease the pain and inflammation of an attack and reduce uric acid levels to prevent further attacks. The stinging nettle contains fine stinging hairs, which are filled with silicic acid and formic acid. A high-quality stinging nettle leaf product will not contain anywhere near enough formic acid to cause concern [ 2 ]. Fresh nettle herb contained high amounts of ascorbic acid [63.75 mg 100 g-1 fresh. The paper turns red in the presence of acid. These hairs contain chemicals, such as formic acid and histamine, that can irritate the skin and cause stinging, itching, and redness. 1. Thoughts on how to prepare and distribute relief goods to calamity stricken areas with the help of Military personnel. Give a reason for your answer. A nettle’s sting is caused by droplets of fluid at the ends of hollow hair-like structures (trichomes) on the undersides of its leaves and along the stem. Increase Your Energy Levels: Nettles are used as a traditional spring tonic to strengthen and support … Why is that the acids in the food and drink you eat do not damage your stomach? 1. Latin: Urtica dioica Also Known As: Stinging nettle, Devil's Apron, Naughty Man's Plaything, Tanging Nettle, Scaddie, Hoky-poky, Devil's Leaf, Heg-beg, Jenny-nettle, Sting-leaf, Ortiga Ancha, Wergulu Family: Urticaceae . ... oxalic acid, tartaric acid, formic acid, and serotonin. Stinging nettles are plants that are commonly found in many areas of the world. Dock leaves actually help relieve a nettle sting because rubbing vigorously releases moist sap from the leaves which has a cooling, soothing effect on the skin. The nettle's name comes from the Latin word 'uro', meaning 'I burn' – appropriately enough given how uncomfortable nettle stings seem to burn! They contain boron, sodium, iodine, chromium, copper, and sulfur. Other folk medicine applications include wound healing, treatment of scalp seborrhea and greasy hair, and gastric juice secretion. A … Stinging nettle (Urtica dioica L.) grows wild in forests, fields and near woodlands in many parts of the U.S. Nettles don;t contain formic acid - that has been disproved. But, as with all drugs, these have side effects that can put patients off them. Stinging nettle rash presents as raised bumps or hives that are often light in color and up to a centimeter in diameter. How could you show that the plant does contain an acid? One small (N = 50) single-blind study using 100 mg/kg of hydroalcoholic nettle extract over 8 weeks showed decreased fasting glucose levels and decreased glycated hemoglobin, but no effect on insulin.66 There is a case report of hypoglycemia due to consumption of nettle preparations for prostatic hypertrophy.67, In vitro studies have shown antiviral action against HIV, cytomegalovirus, coronavirus, rotavirus, and feline immunodeficiency virus.68, 69, 70, 71 Antibacterial action against both plant and human pathogens has also been described.20, 72, 73, 74, 75, 76, 77 A clinical trial with some methodological limitations78 evaluated the adjunctive effect of U. dioica as a combination preparation in treating bacterial prostatitis.79, Antioxidant action of U. dioica has been evaluated. The sting is caused by a chemical reaction and it is delivered through the long hairs that cover the leaves and stems. The nettle sting contains irritants – mainly formic acid and histamines – that are injected into the surface layer of the skin cells. Nettle sting is acidic: it is mainly formic acid, but some species of nettle also have oxalic acid and tartaric acid. Both of these chemicals can cause severe stinging and inflammation upon contact. In country sides stinging neetles are an unpleasant supplement plant. Standardization of commercial preparations is lacking. Why is that the acids in the food and drink you eat do not damage your stomach? A stinging-nettle plant may contain an acid that is injected into your skin when you touch it. Clinical trials for BPH have used aqueous extracts of U. dioica root in dosages of 360 mg daily over 6 months and methanol root extract in dosages of 600 to 1,200 mg daily for 6 to 9 weeks. Nettle fruit contains protein, mucilage, and fixed oil (primarily carvacrol [38%], carvone [9%], and naphthalene [9%]).2, 9, 10, 11 Nettle stings contain acid (formic acid) but they also contain histamine and other chemicals. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Mutagenicity and carcinogenicity studies using the aqueous extract have been negative. This information shows the chemicals: Recent research has revealed the cause of the sting to be from three chemicals – a histamine that irritates the skin, acetylcholine which causes a burning sensation and serotonin, that encourages the other two chemicals. Stinging nettle root has a significantly different chemical profile than the leaves, with about half the quinic acid and almost no caffeic acid by comparison. With Bidets cabinet picks all radicals from the alt-left. Nettle sting is acidic: it is mainly formic acid, but some species of nettle also have oxalic acid and tartaric acid. A stinging-nettle plant may contain an acid that is injected into your skin when you touch it. May Reduce Inflammation. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Stinging nettles can work to clear out this excess uric acid and relieve some symptoms of the disease. The nettle sting contains formic acid as well as histamine and it is this combination that causes the initial reaction when you are stung. Scientific Name(s): Urtica dioica L., Urtica urens L.Common Name(s): Nettle, Soii (Kashmiri), Stinging nettle. How could you show that the plant does contain an acid? Ways To Use Stinging Nettle. This information should not be used to decide whether or not to take this product. Urticaria is named for the stinging nettle plant (Urtica dioica), which contains histaminic acid. Radix urticae extracts and other nettle preparations are generally well tolerated; minor and transient gastric effects, including diarrhea, gastric pain, and nausea, have been reported. Last updated on Apr 21, 2020. Claims of activity against diabetes, cancer, eczema, rheumatism, hair loss, and aging have not been substantiated. The tender tips of young nettles have been used as a cooked potherb in salads. The more buttermilk (acid) you add, the lower the Ph. Extracts of the leaves have been used topically for the treatment of rheumatic disorders. Available for Android and iOS devices. It often grows in patches and may reach 3 feet high or taller. A dock weed plant commonly grows in the same general areas as the stinging nettle plant. The little hairs are brittle, and they break off and cling to hair and skin, which can cause irritation, itching, redness, and swelling. Explanation: Formic acid is certainly capable of causing a stinging sensation. There are no clinical data regarding the use of nettle in conditions of the CNS. Urtica dioica Urtica dioica subsp. Stinging nettle above ground parts contain large amounts of vitamin K. Vitamin K is used by the body to help blood clot. The dock leaves themselves contain oxalic acid, which deters herbivores from eating them. Their stings cause tingling, inflamation and pain. ~ The sting of Nettle leaf has been shown to be beneficial in treating osteoarthritic pain at the base of the thumb or index finger in a randomised, double-blind, controlled, crossover trial. The exact details are still unknown but it is the histamine that causes the initial reaction when you are stung. Soap is also an alkaline. The reason for this is that stinging nettles contain fine hairs and chemicals that irritate human skin. In country sides stinging neetles are an unpleasant supplement plant. … It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Phytonutrients found in stinging nettle include omega 3 fatty acids, phenols, carotenoids, and chlorophyll (17). Stinging nettle (Urtica dioica) is found throughout Eurasia, North America, and northern Africa, and has been introduced to parts of South America. When you add buttermilk (an acid) to baking soda (a base) in a mixing bowl, does the pH increase or decrease? Nettle. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. The chemical content found in the juice from the leaves and stem of a jewelweed plant is reportedly effective at counteracting the sting from a stinging nettle. They also contain tannic and gallic acids, gum, and wax. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This substance cleanses and detoxifies the body regenerating hair cells (20). (without touching it) 2. Nettle stings contain acid (formic acid) but they also contain histamine and other chemicals. Stinging nettle can be eaten on its own or as an ingredient in foods. This information is not specific medical advice and does not replace information you receive from your health care provider. Microscopically, these hairs look like fine needles. Dock leaf sap contains a natural antihistamine, which helps to ease the stinging sensation. If a living being touches these needles, they break off and dig into the skin. Anti-inflammatory and antioxidant effects of nettle extracts appeared to be protective in models of neurodegeneration in rodent studies.48 In a study in diabetic mice, nettle leaf extract improved memory and reduced depression-like behavior.49 In another study in diabetic rats, nettle extract improved cognitive function and increased pain threshold.50. A product called Ankaferd blood stopper contains stinging nettle, common grape vine, thyme, licorice, and alpinia. Autoimmune disorders can destroy body tissues, cause abnormal organ growth or. Formic acid, the same chemical found in ant and bee stings, is present in the stinging liquid and has traditionally been blamed for the sting. (without touching it) 2. Underground rhizomes have the capacity to sting as well. $421M in debt: Trump calls it 'a peanut,' but challenges lie ahead. Actually Doc Leaves do neutralize the formic acid that the nettle stings contain, because it contains alkali that reacts to the acids in the nettles, and soothes the pain. In vitro studies suggest effects on Langerhans and muscle cells, with increased glucose uptake into cells and reduced intestinal absorption of glucose by inhibition of alpha-amylase.51, 52, 53, 54, 55, 56, 57, Serum glucose levels were reduced in some44, 50, 54, 58, 59, 60, 61 experiments in rats with induced diabetes.54, 59, 62 Nettle extracts had no effect on renal indices in diabetic rats63; however, protective effects on the liver, seminiferous, and nervous system tissue were observed in diabetic rats.50, 64, 65, Limited clinical studies have been conducted with nettle extracts alone. Is it because before going to the stomach they get neutralised in the mouth and oesophagus etc. This liquid contains formic acid (poison that causes burning and itching), of nettle can cause digestive problems such as heartburn, stomach ache and. Mechanisms involve agents other than IgE–anti-IgE complexes. The sting also contains serotonin, histamine and choline. The stems and leaves of stinging nettle are covered with needle-like hairs, called trichomes, and each trichome contains a mix of irritating compounds, including histamine, acetylcholine, serotonin, and formic acid (via Brooklyn Botanical Garden). When disturbed, they inject histamine, formic acid, serotonin, and acetylcholine, which produces an irritating, uncomfortable stinging sensation at the point of contact. Nettle hairs contain high levels of leukotrienes and histamine Nettle cloth linens at least 3000 years were recently discovered in burial mounds located in modern-day Denmark. Nettle or placebo was stroked over the painful area daily. The tiny, stinging hairs contain formic acid and a bit of histamine. The effects of the stinging hairs of Urtica species, particularly some subspecies of Urtica dioica, have been attributed to a number of substances, including histamine, acetylcholine, serotonin, and formic acid. Tartaric acid and oxalic acid are also the two compounds to enhance the stingling sensation. U. dioica and U. urens are botanically very similar; they are often distributed together in the wild and considered therapeutically interchangeable. Reduced inflammation in induced paw edema was also demonstrated. Is it because before going to the stomach they get neutralised in the mouth and oesophagus etc. of 80% ethanol and was boiled for 10 minutes to reflux. Dosages of 600 mg of freeze-dried nettle leaf have been used in a clinical trial for allergic rhinitis. The leaves and young stems of this herbaceous plant are fitted with stinging hairs tipped with formic acid and other irritants. The actual science behind the use of plants to treat this condition is very limited. A jewelweed plant is the same plant as an impatiens. Nettle; Folk Law and Traditional Uses Nettle as Food . It has deeply toothed leaves and fine hairs that release histamines and formic acid when touched; these substances are similar to the compounds released by bees or fire ants, according to Purdue University. There are also traces of oxalic acid and tartaric acid. I just need 3 as I am doing a paper.? Tartaric acid and oxalic acid are also the two compounds to enhance the stingling sensation. Stinging nettle is versatile. Stinging nettle is well known for its poisonous hairs that contain formic acid and histamine. These hairs act like a needle which transfers histamine and formic acid into the surface of your skin. Select one or more newsletters to continue. The stinging hairs on nettle are sharp polished spines that contain histamine, methanoic acid and formic acid, irritating chemicals that are released when the plant comes in contact with the skin. The nettle sting contains formic acid as well as histamine and it is this combination that causes the initial reaction when you are stung. What is the best time for study? No alterations in prostate-specific antigen or testosterone levels were reported in a clinical trial.35, Other industry-sponsored clinical studies have used combination preparations, such as saw palmetto with nettle extract, and demonstrated a positive but small effect on nocturia in BPH (absolute reduction of 0.2 voids per night; P = 0.0015).38, American Urological Association guidelines for the management of BPH conclude that there are not sufficient high-quality, single-extract clinical trials using U. dioica to recommend or discourage its use in the treatment of lower urinary tract symptoms secondary to BPH.39, Nettles have traditionally been used for their diuretic and hypotensive effects. Due to the effects on androgen and estrogen metabolism, nettle preparations are contraindicated in pregnancy and lactation and should not be used in children younger than 12 years. Adverse effects have been documented; nettle is a reputed abortifacient and has demonstrated effects on androgen and estrogen metabolism.2, 97, Case reports are lacking2; however, the American College of Cardiology Foundation recommends caution because of possible potentiation of diuretic effects.98 In an experiment with rat platelets, crude aqueous extracts and the isolated flavonoids inhibited platelet aggregation40; however, an in vitro study using human blood samples found no effect on platelet function.41 Studies in rats found some effect of the seed extract on the cytochrome P450 enzyme system and on glutathione S-transferase, suggesting potential for interactions.99, Nettles are primarily known for their ability to induce acute urticaria following contact with exposed skin, which generally resolves spontaneously and is caused by the release of histamine, serotonin, and choline from the hairs and spines of the leaves and stem. 3. The tiny, stinging hairs contain formic acid and a bit of histamine. The more acidic something is, the LESS alkaline it is (the acid neutralizes the base). It exists as a powder or liquid and has been added to topical creams and pills. It contains on average 22% protein, 4% fats, 37% non-nitrogen extracts, 9-21% fiber, and 19-29% ash. Screening studies have evaluated nettle extracts for antiproliferative effect with varying results.11, 89 While activity in human prostate cancer cells has been demonstrated,90 no clinically important apoptosis in human cancer cell lines has been reported,89 and no relationship between flavonoid content and antiproliferative effects has been noted.12 Animal and human studies are lacking. sitosterol in nettle root (<0.01% of total mass) is unlikely to have an effect on BPH, given that 60 mg beta-sitosterol daily is the usual amount necessary to reduce symptoms.8 Urtica dioica agglutinin (UDA) is a heat- and acid-resistant lectin found in stinging nettle, primarily the root. Join Yahoo Answers and get 100 points today. The plant also contains B-group vitamins and vitamin K, along with other acids. Nettles are primarily used in the management of benign prostatic hyperplasia (BPH), diabetes, and arthritis. Lowers Blood Pressure – Stinging nettle is a good vasodilator and thus helps to lower blood pressure. It often grows in patches and may reach 3 feet high or taller. Yet, this has been common practice in treating a sting from a nettle plant for centuries. A combination product includes nettle to treat hyposecretory gastritis.2, Varying chemical constituents of the plant's leaf, flower, seed, and root have been used.2 Phenolic compounds in the root, stalk, and leaves have been described.4, 5, 6 Compounds with possible clinical relevance include nettle root lignans (including divanillyltetrahydrofuran), lectin, U. dioica agglutinin, 9-hydroxy-10 trans-12-cis-octadecadienic acid, steroidal compounds (including stigmasterol, stimast-4-en-3-one, campesterol, and others), polysaccharides, and caffeic and malic acids.2, 7, 8, 9 The plant has been used as a commercial source of chlorophyll, and the young shoots are rich in carotene and vitamin C. The plant also contains B-group vitamins and vitamin K, along with other acids. There are no clinical data regarding the use of nettle in cardiovascular conditions. There are also traces of oxalic acid and tartaric acid. The children should discover that nettle venom is acid (it actually contains oxalic acid). This product may be unsafe when used before surgery or other medical procedures. The reason for this is that stinging nettles contain fine hairs and chemicals that irritate human skin. One study35 showed a modest reduction in prostate size when measured via transrectal ultrasound. Is it because before going to the stomach they get neutralised in the mouth and oesophagus etc. Adverse effects have been documented. These healthy fats are known for their antioxidant properties in heart disease prevention. Treatment with systemic antihistamines and topical steroids may be of benefit.13, 100 Case reports of prolonged effects exist101; 1 case report describes generalized urticaria and elevated IgE levels in a neonate due to contact with maternal skin to which a nettle extract had been applied.84, Radix urticae extracts and other nettle preparations are generally well tolerated; minor and transient gastric effects, including diarrhea, gastric pain, and nausea, have been reported.2 There is a case report of hypoglycemia due to consumption of nettle preparations for prostatic hypertrophy; cases of gynecomastia and galactorrhea due to consumption of nettle tea have also been identified.67, 55 Clinical studies using nettles in BPH report no adverse effects at the doses used.35, 36, 37, Due to the effects on androgen and estrogen metabolism, nettle preparations are contraindicated in pregnancy and lactation and should not be used in children younger than 12 years.2, 97, The oral median lethal dose in rats is estimated to be greater than 30 g/kg for the aqueous leaf extract and 1.3 g/kg for the root.2, 9, 42 Liver function tests in rats fed aqueous nettle extracts for 30 days were normal.42 A dose of 2 g/kg of leaf extract caused diarrhea and diuresis in rats.76 Mutagenicity and carcinogenicity studies using the aqueous extract have been negative.9. A stinging-nettle plant may contain an acid that is injected into your skin when you touch it. These plants also grow naturally in the same areas where you may come across a stinging nettle. We used to think that the main component was formic acid, the same compound contained in ant venom. The stems and leaves of stinging nettle are covered with needle-like hairs, called trichomes, and each trichome contains a mix of irritating compounds, including histamine, acetylcholine, serotonin, and formic acid (via Brooklyn Botanical Garden). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Stinging hairs of nettles are hollow, pointed cells with a tip made of pure silica, which breaks leaving a jagged point when you brush against it. Researchers have also linked tartaric and oxalic acid (found in some species) to the unrelenting pain of a nettle sting. Explanation: Formic acid is certainly capable of causing a stinging sensation. Nettle sting is a natural source of tartaric acid. So, one of the best, most delicious ways to use nettles raw is to blend them into a smoothie. Skin goes into rapid repair on first contact; your own receptors contain proteins – called interferons – that start to reinforce from the inside out while serotonin gets to work to combat swelling and heal, boosting collagen and elastin. Formic acid, also known as methanoic acid, but that is not the only active ingredient.